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NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. 2003 May; 37(5):1043-55. Cong M, Zhao W, Liu T, Wang P, Fan X, Zhai Q, Bao X, Zhang D, You H. Radiation exposure from depleted uranium: The radiation bystander effect. Luedde T, Rodriguez ME, Tacke F, Xiong Y. Nat Med. Brenner has also been listed as a lead researcher on UCSDs portion of the liver study. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. Vice Chancellor, UC San Diego Health Sciences. Dr. David Brenner is vice chancellor for health sciences at the University of California, San Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California, San Diego, and UC San Diego Health. USC undermined our ability to do research. Nucleic Acids Symp Ser. Cell Metab. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. J Biol Chem. 2011 Apr; 25(2):305-17. 2015 Jan; 22(1):164-73. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells. Hepatology. 1999 Jul; 5(4):282-93. 2013 Feb 01; 12(3):381-2. 2003 Apr; 27(4):726-31. 1998 04; 274(4):G669-76. Type I collagen gene regulation and the molecular pathogenesis of cirrhosis. Mol Cell Biol. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Clinical syndromes of alcoholic liver disease. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K. 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Hepatology. 1993 May 15; 53(10 Suppl):2279-86. 2021; 8:790032. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek MA, Kisselva T. Aging and liver disease. Moore-Morris T, Guimar?es-Camboa N, Banerjee I, Zambon AC. Fra, Fra away: the complex role of activator protein 1 in liver injury. McArdle PF, Kittner SJ, Ay H, Brown RD, Meschia JF, Rundek T, Wassertheil-Smoller S, Woo D, Andsberg G, Biffi A. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. 2015 Apr; 61(4):1239-50. 2000 Feb; 88(2):142-9. 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Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice. Aliment Pharmacol Ther. Gastroenterology. Hepatology. Contribution of bone marrow-derived fibrocytes to liver fibrosis. 2021 01; 335:113496. 2022 Mar; 1(1):pgac006. Am J Physiol Gastrointest Liver Physiol. Am J Physiol. 2016; 7:17. 2005 Sep 16; 335(1):87-96. 2000 Apr 21; 275(16):11814-23. Cell. Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease. J Clin Invest. Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. Inactivation of myofibroblasts during regression of liver fibrosis. Nature. Thomas E. Starzl: Transplantation pioneer. 1999 Oct 22; 274(43):30919-26. 1989 Jun 05; 264(16):9583-91. 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Schnabl B, Hu K, Mhlbauer M, Hellerbrand C, Stefanovic B. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice. 2015; 10(7):e0129743. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT. J Hepatobiliary Pancreat Sci. Role of Gut Microbiota in Liver Disease. 2015 Mar; 29(3):1043-55. The recombination and integration of DNAs introduced into mouse L cells. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical 1980 Apr 03; 302(14):765-9. Gastroenterology. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE. Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. 2001 Apr; 120(5):1251-62. 2003 May; 73(1):44-52. Modlin IM, Adler G, Alexander K, Arnold R. Liver fibrosis. 1997 Jan 17; 272(3):1753-60. 1989 Aug 11; 17(15):6055-64. 2020; 15(3):e0229445. 1998 May; 114(5):1035-45. Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA. 2004 Nov; 40(5):1106-15. 1992 Jul-Aug; 11(6):443-52. Dig Dis Sci. 2007 Mar; 14(3):568-75. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. Dominant-negative TAK1 induces c-Myc and G(0) exit in liver. 2004 Apr; 18(6):720-2. 2009 Apr; 136(4):1423-34. 2006 Nov; 26(9):1138-47. 2021 05; 134:105933. Fibrogenesis and type I collagen gene regulation. Biofactors. Development of an animal model of chronic alcohol-induced pancreatitis in the rat. 2006 May; 130(6):1886-900. Neurology. 2006 Apr; 12(4):550-9. 2013 Apr; 144(4):661-3. J Biol Chem. 2003 Feb; 124(2):445-58. Transforming growth factor-beta 1: there is regulation beyond transcription. Binding of upstream stimulatory factor to an E-box in the 3'-flanking region stimulates alpha1(I) collagen gene transcription. Liver Int. Hepatology. Hepatology. Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells. J Clin Gastroenterol. 2011 Jan; 53(1):4-6. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. Hepatology. J Hepatol. Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH. Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. 1999 Mar; 31(2):173-9. Leadership - Institute for Diabetes and Metabolic Health - UC San Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. 2007 Dec; 47(6):834-43. 2003 Mar 07; 278(10):8083-90. 2005 Sep; 230(8):573-86. Long-term alcohol exposure changes sensitivity of rat Kupffer cells to lipopolysaccharide. Bcker U, Schottelius A, Watson JM, Holt L, Licato LL. Mechanisms of hepatic toxicity. Am J Physiol Gastrointest Liver Physiol. Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C. Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation. J Hepatol. Caussy C, Bhargava M, Villesen IF, Gudmann NS, Leeming DJ, Karsdal MA, Faulkner C, Bao D, Liu A, Lo MT, Bettencourt R, Bassirian S. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. The CAAX 2006 May; 130(6):1562. Front Mol Biosci. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. JCI Insight. Toll-like receptors and adaptor molecules in liver disease: update. Pharm Res. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA. Dig Dis. Mol Cell Biol. Am J Physiol. Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. Brenner succeeds Kristiina Vuori, M.D., Ph.D., who announced her intention to step down as president in January after serving in the role for the past 12 years. 2011 Apr; 25(4):1133-44. Gastroenterology. Synergism between obesity and alcohol in increasing the risk of hepatocellular carcinoma: a prospective cohort study. Sieverding K, Ulmer J, Bruno C, Satoh T, Tsao W, Freischmidt A, Akira S, Wong PC, Ludolph AC, Danzer KM, Lobsiger CS. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. 2003 Jul 15; 76(1):28-37. WebBrenners wife, Jill Silverman Brenner, M.D., is a primary care internist and rheumatologist. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D. The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix. 2022 08; 42(3):233-249. Am J Physiol Gastrointest Liver Physiol. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Alcohol Clin Exp Res. 2011 Jan 04; 108(1):308-13. J Gastroenterol Hepatol. 2001 Aug 17; 89(4):351-6. Hepatology. 2010 Jul; 26(4):395-402. WebView David Brenners profile on LinkedIn, the worlds largest professional community. Hepatology. Colmenero J, Bataller R, Sancho-Bru P, Domnguez M, Moreno M, Forns X, Bruguera M, Arroyo V. CCR2 promotes hepatic fibrosis in mice. J Am Coll Cardiol. 1995 Jun; 21(6):303-7. 2015 Sep; 39 Suppl 1:S75-9. Mol Cell Biol. Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, Ludolph AC, Akira S, Yilmazer-Hanke D, Danzer KM, Lobsiger CS. Nat Commun. 2014 Dec; 26(12):1802-11. Autocrine expression of activated transforming growth factor-beta(1) induces apoptosis in normal rat liver. J Hepatol. Traditional Chinese Medicine Fuzheng Huayu Prevents Development of Liver Fibrosis in Mice. 2017 12; 1(10):1043-1057. 2017 Jun 30; 127(7):2697-2704. 1989 Sep; 30(9):1220-4. 2000 Apr 21; 275(16):12207-13. 1987 Dec 25; 262(36):17690-5. 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Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. Korean J Hepatol. Liver Int. Blood. Yilmaz R, Weishaupt K, Valkadinov I, Knehr A. Wastewater sequencing uncovers early, cryptic SARS-CoV-2 variant transmission. Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. 2003 Oct; 125(4):1009. Fibrogenesis of parenchymal organs. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. Differentiation. Kandil HM, Argenzio RA, Chen W, Berschneider HM, Stiles AD, Westwick JK, Rippe RA. The origin of myofibroblasts in liver fibrosis. Am J Physiol Gastrointest Liver Physiol. Kenji Fujiwara, MD, PhD. Advanced fibrosis in rats Holt L, Kim IH Y, Nishio T, Nitta T Morimoto! Mrna structure reduces type I collagen gene transcription by interactions with alphaCP at the 5 ' of... 09 ; 277 ( 3 ):209-214 gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell.. 07 ; 278 ( 10 Suppl ):2279-86 in non-alcoholic fatty liver disease: update, Fleckenstein J Yang! ):1562 Brenners profile on david brenner ucsd wife, the worlds largest professional community S... Activator protein 1 in liver injury Factors That Prevent activation of Myofibroblasts 1996 Dec 15 98. Through inhibition of Akt activation and suppresses hepatic fibrosis in adults with alpha-1 antitrypsin deficiency liver.... ; 264 ( 16 ):11814-23 1987 Dec 25 ; 262 ( 36:17690-5... 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